Ozone therapy is probably the most effective method of oxidation of body liquids and it is natural for human body, as it is actually produced endogenously by immune cells (neutrophils). The mechanisms of action partly consist of creating reactive oxygen species (peroxides) known as ozonides, in the lipid of cell membranes. Ozonides are stable for days or weeks, easily penetrate cell membranes and selectively stimulate numerous biochemical reactions and physiological processes, such as

• Mitochondrial resuscitation and recovery
  
• Increasing oxygen utilization by oxidizing NADH to NAD
  
• Increasing cytokine reduction leading to
  
  • Greater immune system response
  • Normalization of TH1/TH2 balance
• Direct killing of pathogenic bacteria, viruses and fungi with no resistance
  
• Decreasing inflammation by reducing NFKb expression
  
• Improving redox balance by activating Nrf2, a "master regulator of CytoProtection².

Ozone therapy has a long and rich history in Western medicine. The gas comprised of molecules with three oxygen atoms was discovered in 1785 in Netherlands and synthesized in 1840. In late 19^th century, it was shown that ozone eliminates microorganisms, and the gas became popular in Europe as an antiseptic. In the US, the first text book on ozone therapy was published already in 1885. Nikola Tesla patented his ozone generator in 1896 and later founded the "Tesla Ozone Co.". In 1911, the first teaching center on ozone therapy was founded at the Loyola University Chicago. In 1957, the first modern ozone generator was built. Now, ozone therapy is widely spread across the world and applied both by Western and alternative doctors. By now, there were over 3000 studies published in ozone therapy of many etiologies. Ozone treatment is recommended to almost any patient with a variety of disease and conditions.

Importantly, ozone therapy is safe. In a fundamental study on treatment safety, a survey of 64 ozone therapist and 5,579,238 treatment sessions revealed only 0.06% of complications.